Based on Computational fluid dynamics, the problem on transient aerodynamic characteristics of sedan and coach crossing each other on road is researched by adopting technology of sliding interface and moving mesh. The car model is MIRA which has been used for many years in foreign country and the coach model was JT6120 which has been tested many times in domestic wind tunnel. The trends and reasons of aerodynamic coefficients changing were obtained from the flow field of simulation results. The quantificational changing of sedan and coach aerodynamic coefficients when they cross each other was obtained. The simulation results indicated that the all aerodynamic coefficients of two vehicles changed large, and the sedan changed much more enormously than the coach. It is different between the trends of sedan and coach aerodynamic coefficients changing. The aerodynamic force was important to the vehicles’ handling stability when they crossing each other.