In order to solve timedependent reliability of concrete bridges exposed to harsh environments,a computational methodology was developed with an improved response surface method and a deterministic degradation process analysis method of concrete bridges.Analysis programs named concrete bridge durability analysis system (CBDAS) and probability index by response surface method (PIRSM) were compiled by FORTRAN 95.The numerical method was implemented to a prestressed concrete simply supported bridge.The variations of various reliability indices in different limit states were analyzed.The results show that reliability index of concrete stress changes from 2.16 at completion 0.82 after 100 years.Mechanical property indices in serviceability limit state of prestressed concrete bridges may even suffer durability problems.The objective of timedependent reliability of concrete bridges is realized with the proposed computational methodology by overcoming the problem that the limit state equation of complex structure is always implicit.