A novel design of fuel delivery system (FDS) with Venturi ejector is presented. Based on the designing experience and Соколов’s theoretical method, an ejector for a high pressure proton exchange membrane fuel cell (PEMFC) system is designed in detail. Analysis of its potential performance has been made across a wide range of operating conditions, both the calculation and test validation are completed well. The results show to increase the ejector outlet pressure and the ejector fluid pressure can improve the ejecting factor; while the effect of working fluid pressure on ejector performance changes with the ejector exit conditions.