Abstract:This study proposed a regional safety prediction model based on the data from Hillsborough County, Florida, USA. By regionalizing the county into 200, 500 and 700 traffic safety analysis zones, we developed a Bayesian spatial model with consideration of spatial autocorrelation to relate crash rate to zonal factors including road network, trip generation etc. By the model results, we investigated the relationships between traffic safety and zone-level factors, as well as the effects of varied zoning schemes on the estimation of factor effects. Results show that compared with the traditional Poisson model and Poisson-lognormal model, the Bayesian spatial model has a better model-fitting; the greater the total zone number, the higher the spatial effects; the factor estimates are robust given a specific zoning scheme; the most significant factor affecting zonal safety is the total road length with speed limit over 35 mph. The present research contributes to the regional safety modeling in context of traffic safety planning.