基于Smith预估器的PCR仪时滞温控系统

Time delay Control System of PCR Instrument Based on Smith Predictor

摘要:

为了解决聚合酶链式反应（PCR）仪温度控制中的纯滞后问题，在试验数据的基础上，基于Matlab搭建仿真模型.仿真结果表明，加入Smith预估补偿环节可以较好地解决纯滞后效应带来的积分累积问题.将仿真得到的方法移植到实际的控制中，可获得良好的控制效果.最后提出添加一个比例 积分 微分（PID）控制器的改进算法，用以解决Smith预估控制算法中鲁棒性不强的问题.

Abstract:

In order to solve the pure time delay problem of temperature control in polymerase chain reaction (PCR) apparatus, a Matlab simulation model was built based on actual experiment data. The simulation results show that the temperature control system with the Smith predictor loop can reduce the accumulated error in integrated loop, which is caused by the pure time delay. The actual PCR apparatus can get a better temperature control effect with the method concluded from the simulation model. Finally, an optimized algorithm of proportion integration division(PID) controller was proposed to improve the robustness of the Smith predictor.