The seismic behavior of solid-web steel reinforced concrete (SSRC) cross-shaped column was investigated through low cycle reversed loading experiment of 4 column specimens with various axial compression ratios, steel ratios and loading directions. The failure process and pattern, load-displacement hysteretic curve and skeleton curve of columns together with ductility were analyzed. The experimental results show that the failure mode of SSRC specimens with large shear span ratio is bending failure. The hysteretic curves are relatively plump. The displacement ductility coefficients are larger than 3. The drift ratios vary from 1/28~1/16. Furthermore a finite element analysis (FEA) considering the interfacial bond-slip between steel and concrete was carried out to simulate the influence of different parameters including axial compression ratio, steel ratio and loading direction on SSRC bearing capacity and ductility. The numerical analysis results agree well with the experimental results. FEA and Test results indicate that SSRC have favorable ductility and plastic deformation, and can be adopted in the construction of high-rise buildings in high seismic fortification zones.