Abstract:This paper presents a fMRI timeseries classification diagnosis model based on particle swarm optimizationsupport vector machine (PSOSVM), which achieves more accurate judgments and distinctions between patients and healthy individuals by deeply analyzing multidimensional timeseries data of brain regions. This approach is significantly different from the other existing related research work in four aspects as follows: Constructing the feature representation for multidimensional timeseries data of brain regions based on the autoregressive (AR) model; Constructing the classification scheme for multidimensional timeseries of brain regions based on the support vector machine (SVM) model; Constructing the parameter optimization strategy for the classification learning based on the particle swarm optimization (PSO) algorithm; Constructing the classification diagnosis framework for fMRI timeseries data by integrating the above feature representation, optimized classification and parameter optimization patterns. With the mental depression disorder (MDD) as a specific case of empirical analysis, our classification diagnosis model has obtained very positive numerical computation results.