Abstract:The isostatic response function was used to calculate the effective elastic thickness of lithosphere profile from East China Sea to East Mariana Basin.The Ryukyu trench and Mariana trench topography toward the ocean side was also used to validate elastic thickness based on the elastic plate bending model with stress load on the toe of plate,and analyzed the effective elastic thickness results of different sections in conjunction with seismic sounding,geological and geophysical research results. Results demonstrate that Two effective elastic thickness values estimated from the isostatic response function curves,large effective elastic thickness values are close,between 20~25km,the lager effective elastic thickness values reflect the regional thermal state of the marine lithosphere elastic characteristics.The smaller effective elastic thickness values reflect the geological process characteristics of different sections.