In order to study the effect law of deck pavement roughness on dynamic response of concrete bridge deck pavement under vehicle random load, vehicle dynamic load was simulated by MATLAB software based on 2-DOF 1/4vehicle model and then applied to 3-D finite entity model of vehicle-bridge-deck pavement coupling vibration through ANSYS software. The results shows that: compared with stress time-history response of a fixed node, the response of extreme value of pavement stress can not only reflect the random character of vehicle load but obtain the most unfavorable response of pavement; at a certain roughness, the magnification coefficient of different stresses are very similar and when deck pavement is uneven, the extreme value of pavement stress are more than one time larger than absolutely smooth pavement; if a set of complete and accurate assessment criteria could be developed for bridge deck pavement, the stress state of deck pavement could be controlled from a macroscopic perspective by monitoring surface roughness.