The multi-ribbed composite wall consists of the frame made of reinforced concrete rib and lightweight aerated concrete block, which are the two principal bearing members. Frame cell is the essential weighted element. Therefore, numerical analysis on frame cell was conducted according to the thermodynamic performance of each material in the multiribbed composite wall. Finite element analysis was carried out based on temperature field contours in different fire loads with ISO834 international heating curves. It was found that the rate of residual bearing capacity increased and then decreased as the heating time increased and mechanical performance are different between one side and double side by the fire. The heated side achieved ultimate load earlier under vertical displacement load. Because of the damage of the fire, the multiribbed composite wall cell is more likely to have outplane displacement.