To study the mechanism of sound radiation induced by vibration of a car side window glass excited by wind turbulent pressure fluctuation, the front side window glass of a test car was considered in this paper. First, based on the equivalent principle, the boundary window seal was set equivalent to series of spring constraints to realize discrete modeling. Then, a MatlabAbaqus joint simulation optimization platform was built to obtain the best equivalent spring stiffness, so that an equivalent model of boundary constrains of side window glass system was established. After that, the power spectral density of the turbulence pressure fluctuation on the side window glass surface was calculated using the Corcos model, which was used as the excitation of the equivalent model to calculate sound radiation in driver’s ear position with FEM. Finally, a laser vibrometer system was applied to obtain the vibration velocity distribution of the side window glass surface, then the radiated interior noise was calculated with BEM method (semisimulation) based on the test data. A comparison of the calculation results of these two methods shows that the frequency spectra characteristics of sound radiation agree well with each other above 200 Hz, which demonstrates the usability of the calculation method of sound radiation based on the equivalent simplified model of side window glass system and the Corcos model as excitation source.