Abstract:The study of the relationship between the design parameters and the cost is helpful to the designers to consider the economics of the project.The system of the relationship between the design parameters and the cost is semi quantitative analyzed through the interpretative structral modelling method(ISM),and the structure of the system is set up.Changes of the design parameters will affect much the cost of the building.The higher the level of the parameter is,the more the influence is.The building size,storey height,numeber of storeies,building shape,total height of the building are the main cost drivers.Taking the residential building as an example,the cost estimating model with the regression model at the foudation of the result of the ISM application is set up.The “ISM+regression model” is a useful method to study to which degree changes in the parameters of the building will affect the cost of that building,and aslo it’s helpful for the quantitative analysis to the relationship between the building parameters and cost.