聚羟基脂肪酸酯在组织工程中的应用

Application of Polyhydroxyalkanoates in Tissue Engineering

摘要:

聚羟基脂肪酸酯（polyhydroxyalkanoate， PHA）是一系列由微生物合成的天然高分子材料，目前已发现有超过150种组成单体不相同的PHA聚合物。由于最常见也是研究最广泛的PHA——聚3?羟基丁酸（PHB）具有优良的生物相容性和生物可降解性，且其降解产物3?羟基丁酸（3HB）对多种疾病具有潜在的治疗功能，PHA相关材料在组织修复与再生领域得到广泛的关注。介绍了不同单体组成的PHA在修复骨缺损、愈合皮肤伤口、重建神经和递送药物等不同组织工程领域的应用，总结了对应的材料制备方法及组织修复机制，为后续PHA的生物医疗应用提供新的思路。

Abstract:

Polyhydroxyalkanoates （PHA） are a series of natural polymers synthesized by microorganisms， with more than 150 monomers and various properties. Since PHA has an excellent biocompatibility and biodegradability， and the degradation product 3HB， the most common and widely studied type of PHA， i.e.， poly （3-hydroxybutyrate） or PHB， has potential therapeutic functions for a variety of diseases， PHA-related materials have received extensive attentions in the field of tissue repair and regeneration. This paper summarizes the application of PHA consisting of different monomers in different tissue engineering fields， including repairing bone defects， healing skin wounds， nerve reconstruction and drug delivery. It also summarizes the relevant preparation methods of materials and mechanisms of tissue repair， which provides a new idea for the future biomedical application of PHA.