Time delay Control System of PCR Instrument Based on Smith Predictor

Abstract:

In order to solve the pure time delay problem of temperature control in polymerase chain reaction (PCR) apparatus, a Matlab simulation model was built based on actual experiment data. The simulation results show that the temperature control system with the Smith predictor loop can reduce the accumulated error in integrated loop, which is caused by the pure time delay. The actual PCR apparatus can get a better temperature control effect with the method concluded from the simulation model. Finally, an optimized algorithm of proportion integration division(PID) controller was proposed to improve the robustness of the Smith predictor.

Key words:polymerase chain reaction (PCR) equipment; Smith predictor; temperature control; pure lag