Application of Polyhydroxyalkanoates in Tissue Engineering

Abstract:

Polyhydroxyalkanoates （PHA） are a series of natural polymers synthesized by microorganisms， with more than 150 monomers and various properties. Since PHA has an excellent biocompatibility and biodegradability， and the degradation product 3HB， the most common and widely studied type of PHA， i.e.， poly （3-hydroxybutyrate） or PHB， has potential therapeutic functions for a variety of diseases， PHA-related materials have received extensive attentions in the field of tissue repair and regeneration. This paper summarizes the application of PHA consisting of different monomers in different tissue engineering fields， including repairing bone defects， healing skin wounds， nerve reconstruction and drug delivery. It also summarizes the relevant preparation methods of materials and mechanisms of tissue repair， which provides a new idea for the future biomedical application of PHA.